The on-going fundamental geopolitical, geoeconomic , social, political and economic transformations in the region of Central Asia as well as in its individual countries create new opportunities and challenges for the Visegrad4 countries. Once a far-away, under-developed, land-locked backwater of the former Soviet space, Central Asia is on its way to become a key transport hub and supplier of energy resources, minerals and agricultural commodities for the countries of the Eurasian super-continent. China’s ambitious One Belt One Road (OBOR) project is creating a vast transport infrastructure that will connect the region with world markets, drastically reducing the presently prohibitively high transport costs. These deep-going changes offer the V4 countries new opportunities for investment and the rapid broadening of trade and economic relations. Thanks to their geographic situation, V4 countries are well-positioned to take advantage of the emerging business opportunities offered by infrastructure development and related projects.